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1

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

Stittelaar, Koert J., Neyts, Johan, Naesens, Lieve, van Amerongen, Geert, van Lavieren, Rob F., Holý, Antonin, De Clercq, Erik, Niesters, Hubert G. M., Fries, Edwin, Maas, Chantal

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 430 KB

english, 2005

2

In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil

Pieter Annaert, Josef J. Tukker, Jan van Gelder, Lieve Naesens, Erik de Clercq, Guy van den Mooter, Renaat Kinget, Patrick Augustijns

Journal:

Journal of Pharmaceutical Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 202 KB

english, 2000

3

Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses

Lieve Naesens, Chad E. Stephens, Graciela Andrei, Arianna Loregian, Leen De Bolle, Robert Snoeck, J. Walter Sowell, Erik De Clercq

Journal:

Antiviral Research

Année:

2006

Langue:

english

Fichier:

PDF, 323 KB

english, 2006

4

Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts

Lieve Naesens, Pascale Bonnafous, Henri Agut, Erik De Clercq

Journal:

Journal of Clinical Virology

Année:

2006

Langue:

english

Fichier:

PDF, 572 KB

english, 2006

5

Norbornane-based nucleoside and nucleotide analogues locked in North conformation

Dejmek, Milan, Šála, Michal, Hřebabecký, Hubert, Dračínský, Martin, Procházková, Eliška, Chalupská, Dominika, Klíma, Martin, Plačková, Pavla, Hájek, Miroslav, Andrei, Graciela, Naesens, Lieve, Leyssen

Journal:

Bioorganic & Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 708 KB

english, 2015

6

The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design

Stevaert, Annelies, Naesens, Lieve

Journal:

Medicinal Research Reviews

Année:

2016

Langue:

english

Fichier:

PDF, 2.19 MB

english, 2016

7

Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.

Saboulard, Didier, Naesens, Lieve, Cahard, Dominique, Salgado, Antonio, Pathirana, Ranjith, Velazquez, Sonsoles, McGuigan, Christopher, {De Clercq}, Erik, Balzarini, Jan

Journal:

Molecular Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 212 KB

english, 1999

8

Airway proteases: an emerging drug target for influenza and other respiratory virus infections

Laporte, Manon, Naesens, Lieve

Journal:

Current Opinion in Virology

Année:

2017

Langue:

english

Fichier:

PDF, 833 KB

english, 2017

9

Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir)

Huchting, Johanna, Vanderlinden, Evelien, Van Berwaer, Ria, Meier, Chris, Naesens, Lieve

Journal:

Antiviral Research

Année:

2019

Langue:

english

Fichier:

PDF, 922 KB

english, 2019

10

Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives

Cihan-Üstündağ, Gökçe, Naesens, Lieve, Şatana, Dilek, Erköse-Genç, Gonca, Mataracı-Kara, Emel, Çapan, Gültaze

Journal:

Monatshefte für Chemie - Chemical Monthly

Année:

2019

Langue:

english

Fichier:

PDF, 959 KB

english, 2019

11

Hemagglutinin cleavability, acid-stability and temperature dependence optimize influenza B virus for replication in human airways

Laporte, Manon, Stevaert, Annelies, Raeymaekers, Valerie, Boogaerts, Talitha, Nehlmeier, Inga, Chiu, Winston, Benkheil, Mohammed, Vanaudenaerde, Bart, Pöhlmann, Stefan, Naesens, Lieve

Journal:

Journal of Virology

Année:

2019

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2019

12

N-benzyl 4,4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction

de Castro, Sonia, Ginex, Tiziana, Vanderlinden, Evelien, Laporte, Manon, Stevaert, Annelies, Cumella, JosÃ©, Gago, Federico, Camarasa, MarÃa JosÃ©, Luque, F. Javier, Naesens, Lieve, Velazquez, Sonsol

Journal:

European Journal of Medicinal Chemistry

Année:

2020

Langue:

english

Fichier:

PDF, 3.01 MB

english, 2020

13

Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine]

Snoeck, Robert, Wellens, Willy, Desloovere, Christian, Ranst, Mark Van, Naesens, Lieve, De Clercq, Erik, Feenstra, Louw

Journal:

Journal of Medical Virology

Année:

1998

Langue:

english

Fichier:

PDF, 234 KB

english, 1998

14

ChemInform Abstract: Alkoxy-5-nitrosopyrimidines: Useful Building Block for the Generation of Biologically Active Compounds.

Antonio Marchal, Manuel Nogueras, Adolfo Sanchez, John N. Low, Lieve Naesens, Erik De Clercq, Manuel Mulguizo

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 74 KB

english, 2010

15

Polycyclic N-Benzamido Imides with Potent Activity against Vaccinia Virus

Eva Torres, María D. Duque, Prof. Dr. Pelayo Camps, Prof. Dr. Lieve Naesens, Dr. Teresa Calvet, Dr. Mercè Font-Bardia, Prof. Dr. Santiago Vázquez

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 294 KB

english, 2010

16

Alkoxy-5-nitrosopyrimidines: Useful Building Block for the Generation of Biologically Active Compounds

Antonio Marchal, Manuel Nogueras, Adolfo Sánchez, John N. Low, Lieve Naesens, Erik De Clercq, Manuel Melguizo

Journal:

European Journal of Organic Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 589 KB

english, 2010

17

Inhibitory effects of 9-(2-Phosphonylmethoxyethyl)adenine and 3′-azido-2′,3′-dideoxythymidine on tumor development in mice inoculated intracerebrally with moloney murine sarcoma virus

Jan Balzarini, Halina Sobis, Lieve Naesens, Michel Vandeputte, Erik De Clercq

Journal:

International Journal of Cancer

Année:

1990

Langue:

english

Fichier:

PDF, 509 KB

english, 1990

18

Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (pmea) in vivo increases when it is less frequently administered

Jan Balzarini, Lieve Naesens, Erik De Clercq

Journal:

International Journal of Cancer

Année:

1990

Langue:

english

Fichier:

PDF, 521 KB

english, 1990

19

Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting

Liesbeth Lenaerts, John H. McVey, Andrew H. Baker, Laura Denby, Stuart Nicklin, Erik Verbeken, Lieve Naesens

Journal:

The Journal of Gene Medicine

Année:

2009

Langue:

english

Fichier:

PDF, 184 KB

english, 2009

20

Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice

Johan Neyts, Jan Balzarini, Lieve Naesens, Erik de Clercq

Journal:

Journal of Medical Virology

Année:

1992

Langue:

english

Fichier:

PDF, 540 KB

english, 1992

21

Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice

Lieve Naesens, Johan Neyts, Jan Balzarini, Antonin Holy, Ivan Rosenberg, Erik De Clercq

Journal:

Journal of Medical Virology

Année:

1993

Langue:

english

Fichier:

PDF, 626 KB

english, 1993

22

Quantitative analysis of human herpesvirus 6 cell tropism

L. De Bolle, J. Van Loon, E. De Clercq, Lieve Naesens

Journal:

Journal of Medical Virology

Année:

2005

Langue:

english

Fichier:

PDF, 400 KB

english, 2005

23

Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis

Georges de Bilderling, Eddy Bodart, Georges Lawson, David Tuerlinckx, Marc Remacle, Lieve Naesens, Erik De Clercq, Robert Snoeck

Journal:

Journal of Medical Virology

Année:

2005

Langue:

english

Fichier:

PDF, 87 KB

english, 2005

24

Heterocyclic rimantadine analogues with antiviral activity

Grigoris Zoidis, Christos Fytas, Ioannis Papanastasiou, George B. Foscolos, George Fytas, Elizaveta Padalko, Erik De Clercq, Lieve Naesens, Johan Neyts, Nicolas Kolocouris

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 174 KB

english, 2006

25

Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues

Tatjana Gazivoda, Silvana Raić-Malić, Vedran Krištafor, Damjan Makuc, Janez Plavec, Siniša Bratulić, Sandra Kraljević-Pavelić, Krešimir Pavelić, Lieve Naesens, Graciela Andrei, Robert Snoeck, Jan Balz

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 605 KB

english, 2008

26

Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure

Rafał Gawin, Erik De Clercq, Lieve Naesens, Mariola Koszytkowska-Stawińska

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 279 KB

english, 2008

27

Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

Pelayo Camps, María D. Duque, Santiago Vázquez, Lieve Naesens, Erik De Clercq, Francesc X. Sureda, Marta López-Querol, Antoni Camins, Mercè Pallàs, S. Radhika Prathalingam, John M. Kelly, Vanessa Rome

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 541 KB

english, 2008

28

Design and synthesis of 1,2-annulated adamantane piperidines with anti-influenza virus activity

Grigoris Zoidis, Nicolas Kolocouris, Lieve Naesens, Erik De Clercq

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 364 KB

english, 2009

29

Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines

María D. Duque, Pelayo Camps, Lenuta Profire, Silvia Montaner, Santiago Vázquez, Francesc X. Sureda, Jordi Mallol, Marta López-Querol, Lieve Naesens, Erik De Clercq, S. Radhika Prathalingam, John M. K

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 265 KB

english, 2009

30

Design and synthesis of bioactive adamantane spiro heterocycles

Nicolas Kolocouris, Grigoris Zoidis, George B. Foscolos, George Fytas, S. Radhika Prathalingham, John M. Kelly, Lieve Naesens, Erik De Clercq

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 155 KB

english, 2007

31

Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity

Gábor Pintér, Ilona Bereczki, Gyula Batta, Réka Ötvös, Ferenc Sztaricskai, Erzsébet Rőth, Eszter Ostorházi, Ferenc Rozgonyi, Lieve Naesens, Mariann Szarvas, Zoltán Boda, Pál Herczegh

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 241 KB

english, 2010

32

Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines

Grigoris Zoidis, Nicolas Kolocouris, John M. Kelly, S. Radhika Prathalingam, Lieve Naesens, Erik De Clercq

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 418 KB

english, 2010

33

Synthesis of a pericosine analogue with a bicyclo[2.2.2]octene skeleton

Zsolt Fejes, Attila Mándi, István Komáromi, Attila Bényei, Lieve Naesens, Ferenc Fenyvesi, László Szilágyi, Pál Herczegh

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 399 KB

english, 2009

34

Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8

Erik De Clercq, Lieve Naesens, Leen De Bolle, Dominique Schols, Ying Zhang, Johan Neyts

Journal:

Reviews in Medical Virology

Année:

2001

Langue:

english

Fichier:

PDF, 172 KB

english, 2001

35

Clinical features and treatment of adenovirus infections

Liesbeth Lenaerts, Erik De Clercq, Lieve Naesens

Journal:

Reviews in Medical Virology

Année:

2008

Langue:

english

Fichier:

PDF, 498 KB

english, 2008

36

Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin

Marco Derudas, Andrea Brancale, Lieve Naesens, Johan Neyts, Jan Balzarini, Christopher McGuigan

Journal:

Bioorganic & Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 674 KB

english, 2010

37

Synthesis of 1,2-annulated adamantane heterocycles: structural determination studies of a bioactive cyclic sulfite

Grigoris Zoidis, Dimitra Benaki, Vassilios Myrianthopoulos, Lieve Naesens, Erik De Clercq, Emmanuel Mikros, Nicolas Kolocouris

Journal:

Tetrahedron Letters

Année:

2009

Langue:

english

Fichier:

PDF, 619 KB

english, 2009

38

(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA]: a purine analogue with trypanocidal activity in vitro and in vivo

Ronald Kaminsky, Cecile Schmid, Yvonne Grether, Antonin HolY, Erik De Clercq, Lieve Naesens, Reto Brun

Journal:

Tropical Medicine & International Health

Année:

1996

Langue:

english

Fichier:

PDF, 674 KB

english, 1996

39

Cytostatic and Antiviral Activity Evaluations of Hydroxamic Derivatives of Some Non-steroidal Anti-inflammatory Drugs

Zrinka Rajic, Ivan Butula, Branka Zorc, Sandra Kraljevic Pavelic, Karlo Hock, Kresimir Pavelic, Lieve Naesens, Erik De Clercq, Jan Balzarini, Monika Przyborowska, Tadeusz Ossowski, Mladen Mintas

Journal:

Chemical Biology & Drug Design

Année:

2009

Langue:

english

Fichier:

PDF, 430 KB

english, 2009

40

Discovery of Dihydro-Alkyloxy-Benzyl-Oxopyrimidines as Promising Anti-Influenza Virus Agents

Mingyan Yu, Ailin Liu, Guanhua Du, Lieve Naesens, Evelien Vanderlinden, Erik De Clercq, Xinyong Liu

Journal:

Chemical Biology & Drug Design

Année:

2011

Langue:

english

Fichier:

PDF, 154 KB

english, 2011

41

Stability of UC-781, in Intestinal Mucosal Homogenates of the Rat, Rabbit, and Pig

Guy Van den Mooter, Geert Stas, Festo Damian, Lieve Naesens, Jan Balzarini, Renaat Kinget, Patrick Augustijns

Journal:

Pharmaceutical Research

Année:

1998

Fichier:

PDF, 300 KB

1998

42

Inhibition of Intestinal Metabolism of the Antiviral Ester Prodrug bis(POC)-PMPA by Nature-Identical Fruit Extracts as a Strategy to Enhance Its Oral Absorption: An In Vitro Study

Jan Van Gelder, Pieter Annaert, Lieve Naesens, Erik De Clercq, Guy Van den Mooter, Renaat Kinget, Patrick Augustijns

Journal:

Pharmaceutical Research

Année:

1999

Fichier:

PDF, 1.09 MB

1999

43

Synthesis of Novel AZA-Analogues of Tiazofurin with 2-[5,5-bis(Hydroxymethyl)Pyrrolidin-2-yl] Framework as Sugar Mimic

Mironiuk-Puchalska, Ewa, Koszytkowska-Stawińska, Mariola, Sas, Wojciech, De Clercq, Erik, Naesens, Lieve

Journal:

Nucleosides Nucleotides & Nucleic Acids

Année:

2012

Langue:

english

Fichier:

PDF, 222 KB

english, 2012

44

Transport, Uptake, and Metabolism of the Bis(pivaloyloxymethyl)-Ester Prodrug of 9-(2- Phosphonylmethoxyethyl)Adenine in an In Vitro Cell Culture System of the Intestinal Mucosa (Caco-2)

Pieter Annaert, Renaat Kinget, Lieve Naesens, Erik de Clercq, Patrick Augustijns

Journal:

Pharmaceutical Research

Année:

1997

Fichier:

PDF, 491 KB

1997

45

Solid state properties of pure UC-781 and solid dispersions with polyvinylpyrrolidone (PVP K30)

Festo Damian, Norbert Blaton, Herman Desseyn, Katrien Clou, Patrick Augustijns, Lieve Naesens, Jan Balzarini, Renaat Kinget, Guy Van den Mooter

Journal:

Journal of Pharmacy and Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 226 KB

english, 2001

46

Design and synthesis of bioactive 1,2-annulated adamantane derivatives

Zoidis, Grigoris, Tsotinis, Andrew, Kolocouris, Nicolas, Kelly, John M., Prathalingam, S. Radhika, Naesens, Lieve, De Clercq, Erik

Journal:

Organic & Biomolecular Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 227 KB

english, 2008

47

ChemInform Abstract: Synthesis of Novel Aza-Analogues of Tiazofurin with 2-[5,5-Bis(hydroxymethyl)pyrrolidin-2-yl] Framework as Sugar Mimic.

Ewa Mironiuk-Puchalska, Mariola Koszytkowska-Stawinska, Wojciech Sas, Erik De Clercq, Lieve Naesens

Journal:

Année:

2012

Fichier:

PDF, 31 KB

2012

48

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

Zhan, Peng, Wang, Liu, Liu, Hong, Chen, Xuwang, Li, Xiao, Jiang, Xin, Zhang, Qiangqiang, Liu, Xinyong, Pannecouque, Christophe, Naesens, Lieve, Clercq, Erik, Liu, Ailin, Du, Guanhua

Journal:

Archives of Pharmacal Research

Année:

2012

Langue:

english

Fichier:

PDF, 532 KB

english, 2012

49

Human herpesvirus 6 DNA polymerase: enzymatic parameters, sensitivity to ganciclovir and determination of the role of the A961V mutation in HHV-6 ganciclovir resistance

Leen De Bolle, Chaysavanh Manichanh, Henri Agut, Erik De Clercq, Lieve Naesens

Journal:

Antiviral Research

Année:

2004

Langue:

english

Fichier:

PDF, 269 KB

english, 2004

50

Introduction to the Special Issue dedicated to Prof. Erik De Clercq for reaching the Professor Emeritus status at the Katholieke Universiteit Leuven

Jan Balzarini, Graciela Andrei, Lieve Naesens, Johan Neyts, Christophe Pannecouque, Dominique Schols, Robert Snoeck

Journal:

Antiviral Research

Année:

2006

Langue:

english

Fichier:

PDF, 63 KB

english, 2006